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M94A2782.TXT
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1994-10-25
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Document 2782
DOCN M94A2782
TI Intensive non specific immunotherapy for AIDS.
DT 9412
AU Cima M; Catapano S; NYU School of Medicine.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):226 (abstract no. PB0334). Unique
Identifier : AIDSLINE ICA10/94369793
AB OBJECTIVE: To test the hypothesis that non specific intensive
immunotherapy may be helpful in the treatment of AIDS. METHODS: Twenty
patients with AIDS not in the terminal phase of the disease were treated
with weekly injections of typhoid vaccine (Catapano's Protocol).
Clinical evolution and lab parameters were evaluated at monthly
intervals for 1 year. No other therapy for AIDS was given with the
exception of medication for opportunistic infections. RESULTS: Clinical
Observations: Resolution of fever and night sweats shrinking of enlarged
lymph nodes, reduction in size and number of Kaposi's Sarcoma lesions,
return of appetite, weight gain, resolution of fatigue and weakness,
marked improvement in AIDS dementia. Laboratory observations: Elevation
of the total white, lymphocytic and platelet counts, raise in
hemoglobin, rise of CD4 count. Side effects were not significant.
DISCUSSION AND CONCLUSIONS: Further studies of this therapeutic modality
alone or in combination with other agents would appear warranted.
DE Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*THERAPY Human
*Immunotherapy, Active Treatment Outcome Typhoid-Paratyphoid
Vaccines/*THERAPEUTIC USE CLINICAL TRIAL MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).